____ served as the highway for explorers, early settlers, and later immigrants.

___ was an early exploration route.

___ were the transportation arteries for farm and industrial products. They were links to ports and other parts of the world.

___ was the gateway to the west.

___ was explored by Lewis and Clark.

___ was explored by the Spanish.

___ forms the border with Mexico.

___ forms part of the northeastern border with the US and Canada.

___ connects the Great Lakes to the Atlantic Ocean.

Inland port cities grew in the Midwest along the ___.

___ provided the French and Spanish with exploration routes to Mexico and other parts of America.

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